Nonencapsulated uniform plump columnar cells with bland nuclei with diverse growth patterns tubular, cribriform, papillary, solid, fascicular, microcystic, single file, pseudoadenoid cystic without true lumens, strandlike, mixed. In such cases, it is critical to make a definite diagnosis as each of these tumors has an entirely different treatment protocol. Owing to the indolent nature of plga and its relatively recent description, the full clinicopathologic spectrum of this entity has not been elucidated fully. Age and sex distribution polymorphous lowgrade adenocarcinoma of salivary gland has been recorded in teens, young, middleaged and elderly adults. Management excision, postoperative radiation therapy. Polymorphous lowgrade adenocarcinoma primary central nervous system lymphoma primary effusion lymphoma. This study is an analysis of the prevalence of polymorphous low grade adenocarcinoma plga in. What are synonyms for polymorphous lowgrade adenocarcinoma. Both lesions were recognized as independent entities in the latest scheme of classification of salivary gland tumors by the world health organization. Pdf polymorphous lowgrade adenocarcinoma plga, is a rare. Polymorphous lowgrade adenocarcinoma december 5 th, 2008. Ckit expression distinguishes salivary gland adenoid. A case report in a male 48 he had history of foul smelling discharge from the mouth.
Histologic transformation of polymorphous lowgrade. This tumor was recognized as a distinct entity in 1983 by freedman and lumerman and batsakis et al. Mixed tumor, polymorphous lowgrade adenocarcinoma and adenoid cystic carcinoma of the salivary gland. Figure 2 a image of polymorphous lowgrade adenocarcinoma comprising irregular. Here, we report a polymorphous lowgrade adenocarcinoma case of the maxillary sinus, a very rare. Salivary gland tumors are a relatively rare and morphologically diverse group of lesions. Paranasal sinuses are uncommon venues for polymorphous lowgrade adenocarcinoma. Polymorphous lowgrade adenocarcinoma plga is a lowgrade malignant neoplasm usually arising in the minor salivary glands. Polymorphous low grade adenocarcinoma of minor salivary gland. Polymorphous lowgrade adenocarcinoma of the nasopharynx. Ce 110 a guide to clinical differential diagnosis of. Common tumor of palate with infiltrative growth, multiple architectural growth patterns and cellular uniformity, first described in 1983 oral surg oral med oral pathol 1983. Polymorphous low grade adenocarcinoma with distant. Immunohistochemical pattern of pleomorphic adenoma.
It has previously been known as terminal duct carcinoma, lobular carcinoma, and lowgrade papillary adenocarcinoma. Polymorphous low grade adenocarcinoma plga is a rare salivary gland neoplasm with an indolent course. Request pdf polymorphous lowgrade adenocarcinoma polymorphous lowgrade adenocarcinoma plga is almost exclusively a minor salivary gland tumour and has been recognised since the early 1980s. In filtrating solid nests and cells growing in an adenoid cystic pattern arranged. Clinical aspects usually the tumor is a painless mass, commonly in the palate, and often of long standing. It is important to differentiate plga from other salivary gland tumors with myoepithelial differentiation such as pleomorphic adenoma and adenoid cystic carcinoma. Polymorphous low grade adenocarcinoma plga is an indolent malignant tumor affecting the minor salivary gland almost exclusively. The term polymorphous lowgrade adenocarcinoma was later adopted in the 2nd who classification of 1991 and defined as a malignant epithelial tumour characterized by cytological uniformity, morphological diversity and a low metastatic potential. Polymorphous lowgrade adenocarcinoma plga is one such tumor, misunderstood.
For language access assistance, contact the ncats public information officer. Although most clinicians and pathologists will have encountered the more common benign neoplasms, few have the experience of all types of salivary cancers, which are best managed in specialist centers. Polymorphous lowgrade adenocarcinoma plga is a lowgrade malignant epithelial tumor that is the second most common malignant neoplasm of minor salivary glands. Polymorphous lowgrade adenocarcinoma of the salivary glands with transformation to highgrade carcinoma. Polymorphous lowgrade adenocarcinomas plga are distinctive salivary. Polymorphous low grade adenocarcinoma of the parotid in a teenager divya khosla1, shalini verma1, nitin gupta2, rajpals punia3, gurbir kaur1, awadheshk pandey1, kislay dimri1 abstract introduction. The list of signs and symptoms mentioned in various sources for polymorphous lowgrade adenocarcinoma includes the 5 symptoms listed below. Polymorphous lowgrade adenocarcinoma is a rare malignancy arising from the minor salivary glands in the aerodigestive system, most frequently the hard palate. Polymorphous lowgrade adenocarcinoma lester dr thompson. If you have problems viewing pdf files, download the latest version of adobe reader. Polymorphous lowgrade adenocarcinoma nord national.
It is most commonly found in the palate the name of the tumor derives from the fact that. We report a case of plga arising from the parotid gland. Polymorphous lowgrade adenocarcinomas are minor salivary gland neoplasms with a predilection for intraoral sites. Polymorphous lowgrade adenocarcinoma genetic and rare. Polymorphous low grade adenocarcinoma plga is a tumor of minor salivary glands that exhibits considerable morphologic overlap with adenoid cystic carcinoma and cellular pleomorphic adenoma, especially in small biopsy specimens.
A guide to clinical differential diagnosis of oral mucosal lesions continuing education brought to you by course author. This parotid epithelialmyoepithelial carcinoma shows a solid growth pattern with scattered tubules and mostly shows elongated nuclei with open chromatin and delicate nuclear membranes reminiscent of. Polymorphous lowgrade adenocarcinoma of salivary gland origin plga was. The list of treatments mentioned in various sources for polymorphous lowgrade adenocarcinoma includes the following list. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126. The immunohistochemical expression ki67 in polymorphous low grade adenocarcinoma of the salivary glands mustafa mohammed abdulhussain department of oral pathology, college of dentistry, almustansiriyah university, baghdad, iraq abstract background. Karyotypic variability and evolutionary characteristics of a polymorphous low grade adenocarcinoma in the parotid gland.
Treatments for polymorphous lowgrade adenocarcinoma. Polymorphous low grade adenocarcinoma castle 1999 cancer. Most patients present with an asymptomatic mass in the hard palate. Pathology afip of plga arising within major salivary glands. Polymorphous lowgrade adenocarcinoma plga is a rare, asymptomatic, slowgrowing malignant salivary gland tumor. It can also occur in minor salivary glands in the rest of the. Polymorphous lowgrade adenocarconoma wexner medical center. Polymorphous adenocarcinoma of the salivary glands university of. Who gets polymorphous lowgrade adenocarcinoma of salivary gland. Comparative immunoprofile of polymorphous lowgrade. Selective immunohistochemical comparison of polymorphous lowgrade adenocarcinoma and adenoid cystic carcinoma.
As the name implies, polymorphous lowgrade adenocarcinoma plga is a lowgrade neoplasm consisting of a uniform population of tumor cells that are arranged in a variety of architectural patterns polymorphous. Women are affected twice as frequently as men, and generally present in the fifth to sixth decade of life with a painless ihaoral mass. Polymorphous lowgrade adenocarcinoma has only rarely been reported in britain, but we believe it deserves wider recognition as a distinct clinicopathological entity and. Pdf polymorphous low grade adenocarcinoma researchgate. Polymorphous lowgrade adenocarcinoma of the parotid.
Polymorphous definition of polymorphous by medical. Polymorphous low grade adenocarcinoma is a rare malignant tumor of minor salivary glands. Polymorphous lowgrade adenocarcinoma of the tongue. The immunohistochemical expression ki67 in polymorphous. Polymorphous lowgrade adenocarcinoma of salivary gland.
Polymorphous low grade adenocarcinomas plgas are thought to be indolent tumours that are localised preferentially to the palate and affect the minor salivary glands almost exclusively. Polymorphous lowgrade adenocarcinoma definition of. Polymorphous lowgrade adenocarcinoma located in the. Polymorphous lowgrade adenocarcinomas are minor salivary gland. Intracytoplasmic nuclear inclusions arrows, a feature found in some tumors. Polymorphous low grade adenocarcinoma has a consistent p63. Polymorphous lowgrade adenocarcinoma plga is a malignant epithelial tumor characterized by cytological uniformity, morphological diversity, an infiltrative growth pattern and low metastatic potential. Treatment list for polymorphous lowgrade adenocarcinoma. A carcinoma commonly misclassified as polymorphous lowgrade adenocarcinoma hematoxylineosin staining used in both parts of figure. Always seek professional medical advice about any treatment or change in treatment plans. Histopathological spectrum of polymorphous lowgrade. Synonyms for polymorphous lowgrade adenocarcinoma in free thesaurus. Recently, two cases of plga with microscopically confirmed distant metastases have been reported.
Polymorphous low grade adenocarcinoma lester dr thompson. Polymorphous lowgrade adenocarcinoma plga is a slowgrowing salivary gland malignancy with a nonaggressive behaviour. The peripheral invasive component showed an indian file pattern of. Acinic cell adenocarcinoma mucoepidermoid carcinoma, low grade polymorphous lowgrade adenocarcinoma monomorphic adenoma gingival cyst of adult lymphoepithelial cyst epidermoiddermoid cyst thyroglossal tract cyst squamous cell carcinoma verrucous carcinoma lymphoma metastatic carcinoma melanoma sarcoma salivary gland adenocarcinoma. Metastases to locoregional lymph nodes occur in only 610% of cases. Polymorphous lowgrade adenocarcinoma plga and canalicular adenoma ca are relatively rare tumors of salivary gland. Objectivethe aim of this case study was to describe an international case series of polymorphous lowgrade adenocarcinoma plga affecting the upper lip. Salivary gland polymorphous lowgrade adenocarcinoma.
Polymorphous low grade adenocarcinoma of the hard palate. The topic salivary gland polymorphous lowgrade adenocarcinoma you are seeking is a synonym, or alternative name, or is closely related to the medical condition polymorphous lowgrade adenocarcinoma of salivary gland. The present case showed predominant single file pattern of tumor cells. The major salivary glands are the parotid glands at the side of the face, below the ears. Polymorphous low grade adenocarcinoma is a low grade adenocarcinoma involving predominantly minor salivary glands, particularly of the palate, where it represents the second most frequent malignant tumor. We report a case of a 55 year old male who presented with an asymptomatic.
Rare cancers genetic and rare diseases information. Polymorphous lowgrade adenocarcinoma of the tongue base. Polymorphous lowgrade adenocarcinoma is a malignant epithelial tumour with low metastatic rate and infiltrative growth pattern. Polymorphous lowgrade adenocarcinoma plga is a rare tumor of the salivary glands that is limited, to a great extent, to the minor salivary glands and commonly, but not exclusively, localized in the palate of the mouth. Plga is predominantly found in females in their sixth to seventh decade, and it most commonly arises in the minor salivary glands, with more than half of cases involving the palate. It has a varied microscopic architectural appearance, i. A 54yearold male presenting with a mass at the base of the tongue performed transoral laser microsurgery.
Its resemblance to lobular carcinoma of the breast had led to its earlier nomenclature of terminal duct carcinoma. Polymorphous lowgrade adenocarcinoma is a distinct neoplasm of the. Polymorphous lowgrade adenocarcinoma of salivary gland origin plga was initially described in 1984 and has since become an established clinicopathologic entity. Polymorphous lowgrade adenocarcinoma is a lowgrade and indolent neoplasm, with 1020% risk of local recurrence, and low risk for distant metastasis and death due to plga. Polymorphous low grade adenocarcinoma of the parotid in a. Polymorphous lowgrade adenocarcinoma is a distinct neoplasm of the salivary gland composed of luminal and nonluminal tumor cells admixed in varying proportions. The treatment of choice is wide surgical resection, and the efficacy of radiotherapy has not been confirmed.
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